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| Riffel,A.; Medina,L.F.; Stefani,V.; Santos,R.C.; Bizani,D.; Brandelli,A.. |
| The antibacterial activity of a series of 1,4-naphthoquinones was demonstrated. Disk diffusion tests were carried out against several Gram-positive and Gram-negative bacteria. The compound 5-amino-8-hydroxy-1,4-naphthoquinone was the most effective, presenting inhibition zones measuring 20 mm against staphylococci, streptococci and bacilli at 50 µg/ml. Methicillin-resistant Staphylococcus aureus and several clinical isolates of this bacterium were also inhibited. Naphthazarin, 5-acetamido-8-hydroxy-1,4-naphthoquinone, and 2,3-diamino-1,4-naphthoquinone were the next most active compounds. The minimal inhibitory concentration of the active compounds was determined against S. aureus, ranging from 30 to 125 µg/ml. All compounds presented a minimal... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 5-Amino-8-hydroxy-1; 4-naphthoquinone Antimicrobial agent Staphylococcus aureus Quinone Naphthazarin 5-Acetamido-8-hydroxy-1; 4-naphthoquinone 2; 3-Diamino-1; 4-naphthoquinone. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000700008 |
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| Silva,D. Scopel e; Castro,C.C.; Silva e Silva,F.; Costa,G.A.; Soares,M.P.; Vargas,G.D.; Fischer,G.; Lima,M.; Brandelli,A.; Motta,A.S.; Hübner,S.O.. |
| ABSTRACT P34 is an antimicrobial peptide produced by Bacillus sp. P34, isolated from the intestinal contents of a fish from the Amazon basin. This peptide showed antibacterial properties against Gram-positive and Gram-negative bacteria and was characterized as a bacteriocin like substance. It was demonstrated that the peptide P34 exhibited antiviral activity against feline herpesvirus type 1 in vitro. The aim of this work was to evaluate P34 for its antiviral properties in vitro, using RK 13 cells, against the equine arteritis virus, since it has no specific treatment and a variable proportion of stallions may become persistently infected. The results obtained show that P34 exerts antiviral and virucidal activities against equine arteritis virus, probably... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Equine arteritis virus; Antiviral therapy; Antimicrobial peptide; Virucidal activity. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352017000300535 |
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| Passos,E.P.; Brugnara,L.; Facin,A.C.; Riffel,A.; Lima,G.R.; Freitas,V.; Brandelli,A.. |
| The effect of peritoneal fluid (PF) on the human sperm acrosome reaction (AR) was tested. Sperm was pre-incubated with PF and the AR was induced by calcium ionophore A23187 and a neoglycoprotein bearing N-acetylglycosamine residues (NGP). The AR induced by calcium ionophore was inhibited 40% by PF from controls (PFc) and 50% by PF from the endometriosis (PFe) group, but not by PF from infertile patients without endometriosis (PFi). No significant differences were found in the spontaneous AR. When the AR was induced by NGP, pre-incubation with PFc reduced (60%) the percentage of AR, while PFe and PFi caused no significant differences. The average rates of acrosome reactions obtained in control, NGP- and ionophore-treated sperm showed that NGP-induced... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acrosome reaction; Endometriosis; Infertility; Peritoneal fluid; Sperm. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000100009 |
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